舞林大会

斯科尔斯：阿森纳有可能夺得三冠王，他们的夏季引援令人恐惧_我的网站

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    Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province. Photo: Scrrenshot from website
A Chinese research team has identified a new potential target to develop antidepressant drug from Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province, according to Kunming University of Science and Technology, Science and Technology Daily reported Sunday.
The team, led by professors Xu Tianrui and Xiang Cheng from the university's School of Life Science and Technology, found that Qingyangshen glycosides, the plant's core active compound, can alleviate depression-related behaviors by simultaneously suppressing inflammation, reducing oxidative damage and stabilizing neurotransmitters in the brain.
The findings were published in the international journal Phytomedicine.  
Depression has become a widespread mental health disorder globally, while existing clinical drugs fail to provide effective treatment for more than 30 percent of patients, according to the researchers. Previous studies have established a strong link between chronic inflammation and depression, but existing anti-inflammatory drugs have limited targeting capabilities, underscoring the need for new therapeutic targets and lead compounds.
Qingyangshen, a plant of the Cynanchum genus in the Apocynaceae family, has long been used as a traditional medicine by ethnic groups including the Naxi, Yi and Bai peoples in Yunnan, mainly for treating neurological conditions such as epilepsy and neurasthenia. 
The researchers systematically examined the pharmacological effects of Qingyangshen extract and its core active compound, Qingyangshen glycosides. Tests using mouse, zebrafish and fruit fly models repeatedly showed that the compound significantly improved depression-related behaviors induced by inflammation, according to the report.
To identify the compound's target, the team developed a dual-discrimination model for four subtypes of prostaglandin E2 receptors and combined it with AI-powered machine learning. The researchers screened hundreds of G protein-coupled receptors and identified the prostaglandin E2 subtype 4 receptor as the direct target of Qingyangshen glycosides.
Multiple molecular experiments confirmed that the compound binds directly to the receptor and acts as an inhibitory ligand. Further experiments involving animals with the receptor knocked out in the hippocampus showed that the antidepressant effects of Qingyangshen glycosides disappeared completely when the receptor was absent, providing the first in-vivo evidence that the receptor is essential for the compound's therapeutic effects.
    An illustration of the research. Photo: Screenshot from the website
The study establishes the prostaglandin E2 subtype 4 receptor as a potential new target for antidepressant drug development and points to a new approach to treating depression through inflammatory pathways. It also identifies Qingyangshen glycosides as a potential lead compound for developing highly targeted anti-inflammatory antidepressants, creating a research chain from ethnic medicinal plants and active compounds to drug targets and new drug development.
Global Times
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二 |     8月26日讯 曼联名宿斯科尔斯表示，阿森纳在本赛季有可能夺得三冠王。阿森纳在上赛季夺得英超冠军，今夏又引进了不少强援，阵容实力进一步提升。

三 | 足球评论员‌迪昂·达布林表示：“你知道吗？我不支持阿森纳夺得三冠王，但也不会排除这种可能性。他们拥有最出色最稳定的阵容，俱乐部内部气氛和谐。他们的足球表现很出色，而阿尔特塔还拥有一个非常强大的替补席，简直强大得令人难以置信。赢得三冠王很困难，但我不会排除他们做到的可能。夺得英超冠军已经够难了，我们要踢好比赛，但我不会排除这种可能性，我不认为这是不可能的。”对此斯科尔斯表示：“我同意这种观点。

四 | 我认为以阿森纳的状态来看，这很有可能。我认为阿森纳在转会期最后一周还有可能会引进另一名新援，这令人恐惧。他们刚签下了孔萨，这是一名顶级后卫。”而加里·内维尔也表示：“本赛季英超冠军100%是阿森纳，他们遥遥领先。以他们目前在后防和中场的实力，以及他们拥有的优秀攻击手，他们的水平非常高，没有问题。

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Published on:17:11:44